Endocrine Abstracts

Aim: to establish a human in vitro system for the study of pituitary cells in culture and subsequently to study the influence of the pro-inflammatory cytokines interleukin (IL)-1β and tumour necrosis factor (TNF)-α on the function of the somatotrophic cells inclusive the ability of the cells to produce IL-6 and IL-8.Methods: Pituitary adenomas were obtained from hypophysectomies of patients with acromegaly. The tissue was enzymatically d...